DETECTABLE AMOUNTS OF ADRENOCORTICOTROPHIC HORMONE IN BLOOD FOLLOWING EPINEPHRINE

Abstract

Blood from control and epinephrine-injd. rats was assayed for ACTH in recipient hypophysectomized rats. The ACTH titer increased following epinephrine injn. The ACTH in blood from control rats was estimated to be 0.026 m. U./cc. One min. after epinephrine admn., the concn. of ACTH in blood was estimated to be 0.064 m. U/cc. The mechanism which controls the blood level of ACTH apparently responds with extreme rapidity to the admn. of epinephrine.