Effect of Progestins on Androgen Δ4-3-Ketosteroid-5α-A-Ring Reductase System in Rat Oral Mucosa
- 1 March 1978
- journal article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 57 (3), 511-519
- https://doi.org/10.1177/00220345780570032001
Abstract
Rat oral mucosa microsomal Δ 4-3-ketosteroid-5α-A-ring reductase enzyme system, reducing testosterone and 4-androstenedione, was found to be inducible by systemic administration of medroxyprogesterone acetate (MPA). MPA, when used in a mixture with testosterone and/ or 4-androstenedione in vitro, acted as a competitive inhibitor of the reduction of these substrates.Keywords
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