Antagonism of inhibitory amino acids by the steroid derivative RU5135
Open Access
- 1 March 1985
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 84 (3), 631-635
- https://doi.org/10.1111/j.1476-5381.1985.tb16143.x
Abstract
1 The steroid derivative RU5135 has been tested for its ability to antagonize glycine and the γ-aminobutyric acid (GABA) analogue muscimol on isolated preparations of rat optic nerve and cuneate nucleus, respectively. 2 On the cuneate nucleus, RU5135 antagonized muscimol in a competitive manner with a pA2 value of 8.31. RU5135 shared a common site of action with bicuculline that was separate from the Picrotoxin site. 3 On the optic nerve, RU5135 antagonized glycine with a pA2 of 7.67. It shared a common site of action with strychnine.This publication has 6 references indexed in Scilit:
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