Lateralization on Neuroimaging Does Not Differentiate Frontotemporal Lobar Degeneration from Alzheimer’s Disease
- 1 June 2004
- journal article
- Published by S. Karger AG in Dementia and Geriatric Cognitive Disorders
- Vol. 17 (4), 324-327
- https://doi.org/10.1159/000077164
Abstract
Lateralization on neuroimaging was compared in cases of frontotemporal lobar degeneration (FTLD; n = 10) and cases of definite Alzheimer’s disease (AD; n = 17). All of the cases were pathologically confirmed and semi-quantitative and statistical parametric mapping methods were employed. Seven of the 10 FTLD cases had lateralization on at least one neuroimaging modality: single photon emission computerized tomography (SPECT), MRI, or CT. All 6/6 FTLD cases with SPECT showed lateralization. MRI results generally agreed with SPECT findings. Three of 4 FTLD cases had lateralized atrophy on CT. For the AD cases, 10/17 SPECTs, 2/7 MRIs, and 1/9 CTs showed lateralized findings. Of the neuroimaging modalities utilized, SPECT was the most sensitive in detecting lateralization.Keywords
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