Amino Acid Uptake by Kidney and Jejunal Tissue from Dogs with Cystine Stones
- 19 December 1969
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 166 (3912), 1525-1527
- https://doi.org/10.1126/science.166.3912.1525
Abstract
Cystine and lysine accumulation in vitro in intestinal and renal tissue was studied in eight dogs that form cystine stones. Under conditions which demonstrate in vitro defects in tissue obtained from humans with cystinuria, normal amino acid accumulation occurred in six dogs with the canine disorder. Normal amino acid uptake in tissue and the demonstration of normal to minimum increases in excretion of lysine suggest that the canine disorder is not similar to the human syndrome.Keywords
This publication has 14 references indexed in Scilit:
- Delineation of separate transport systems in rat kidney cortex for L-lysine and L-cystine by developmental patternsBiochemical and Biophysical Research Communications, 1969
- Thin-layer chromatographic separation of cystine and the N-ethylmaleimide adducts of cysteine and glutathioneAnalytical Biochemistry, 1969
- Hyperdibasicaminoaciduria: An Inherited Disorder of Amino Acid Transport[34]Pediatric Research, 1968
- Isolierter Defekt der tubulären Cystin-Rückresorption in einer Familie mit idiopathischem HypoparathyroidismusKlinische Wochenschrift, 1967
- Cystinuria: biochemical evidence for three genetically distinct diseases.JCI Insight, 1966
- Heterozygotes for cystinuriaAnnals of Human Genetics, 1966
- Intestinal absorption of lysine in cystinuric dogsJournal of Comparative Pathology, 1965
- Cystinuria: Defective Intestinal Transport of Dibasic Amino Acids and Cystine*JCI Insight, 1965
- Evidence against a Single Renal Transport Defect in CystinuriaNew England Journal of Medicine, 1964
- Transport of amino acids by slices of rat-kidney cortexBiochimica et Biophysica Acta, 1961