METHOD FOR OBTAINING UTERINE FLUID FROM THE MONKEY: EFFECT OF PILOCARPINE, ATROPINE, PHYSIOLOGICAL SALT SOLUTION AND ADRENALIN

Abstract

The article describes a method for collecting uterine fluid in the rhesus monkey through a utero-abdominal fistula much like that described in 1940 by van Wagenen and Morse. After preliminary observations on the normal rate of flow, attempts were made to alter it with pilocarpine, atropine, physiological salt soln. and adrenalin. Pilocarpine did not cause an increase in secretion rate as previously reported for the bitch. On the contrary, large doses depressed the flow of uterine fluid. Adrenalin and intraven. saline, however, increased the rate of flow. There is some evidence that factors which influence the rate of blood flow locally or cause systemic blood vol. changes may produce alterations in the rate of formation of uterine secretions. This method appears to lend itself to the further study of cyclic variations in the physical and chemical characteristics of uterine fluid in the monkey.