Anti-Tubercular Activity in vivo of Nicotinaldehyde Thiosemicarbazone and Its Isomers
- 1 May 1951
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 77 (1), 47-50
- https://doi.org/10.3181/00379727-77-18673
Abstract
(1) The anti-tubercular activity of the thiosemicarbazone of nicotinaldehyde in the intravenous infection of mice with M. tuberculosis as described by Levaditi was confirmed. (2) The thiosemicarbazone of isonicotinaldehyde was found as active as the thiosemicarbazone of nicotinaldehyde and the effect of both compounds was comparable to that of Tibione. Picolinaldehyde thiosemicarbazone was ineffective. (3) The thiosemicarbazones of nicotinaldehyde and isonicotinaldehyde also were found appreciably active in the therapeutically more resistant bronchogenic type of tuberculosis of mice produced by intranasal infection. Under these experimental conditions the compounds appeared superior to Tibione.Keywords
This publication has 6 references indexed in Scilit:
- THE CHEMOTHERAPY OF EXPERIMENTAL TUBERCULOSIS IIJournal of Bacteriology, 1950
- CHEMICAL STUDIES ON THIOSEMICARBAZONES WITH PARTICULAR REFERENCE TO ANTITUBERCULOUS ACTIVITYPublished by Elsevier ,1950
- INVESTIGATIONS ON THE ANTITUBERCULOUS ACTIVITY OF THE THIOSEMICARBAZONES INVITRO AND INVIVOPublished by Elsevier ,1950
- THE USE OF THE MOUSE FOR THE TESTING OF CHEMOTHERAPEUTIC AGENTS AGAINST MYCOBACTERIUM TUBERCULOSISAnnals of the New York Academy of Sciences, 1949
- EFFETS CURATIFS DU THIOSEMICARBAZONE (TB1) DANS LA TUBERCULOSE EXPERIMENTALE DE LA SOURIS1949
- THE EFFECT OF NICOTINIC ACID AMIDE ON EXPERIMENTAL TUBERCULOSIS OF WHITE MICE1948