Effect of Nitro--Compounds and Aldehyde Semicarbazones on Virus of Primary Atypical Pneumonia.

Abstract

Chloramphenicol inhibited the growth of primary atypical pneumonia virus in chick embryos when injected into the yolk sac as a single dose of 5 mg./hr. after amniotic inoculation of virus. Less definite inhibition of the growth of this virus in chick embryos was observed with 2 derivatives of 5-nitro-2-furaldehyde semicarbazone. Cotton rats infected intranasally with the virus of atypical pneumonia were treated by intraperit. injn. of several different cyclic aldehyde semicarbazone and thiosemicarbazone derivatives. Most marked suppression of the pulmonary lesions was obtained with substituted 5-nitro-2-furaldehyde semicarbazones, p-nitrobenzaldehyde semicarbazone, and p-acetylaminobenzaldehyde thiosemicarbazone.