Striatal Protection Induced by Lesioning the Substantia Nigra of Rats Subjected to Focal Ischemia
- 1 September 1992
- journal article
- Published by Wiley in Journal of Neurochemistry
- Vol. 59 (3), 1153-1157
- https://doi.org/10.1111/j.1471-4159.1992.tb08358.x
Abstract
Unilateral 6-hydroxydopamine lesion of the substantia nigra reduced the volume of striatal necrosis and suppressed the increase in extracellular glutamate concentration in the striatum induced by middle cerebral artery occlusion in rats. These results indicate that the dopaminergic nigrostriatal pathway is highly involved in the vulnerability of the striatum to ischemia and suggest that glutamate-dopamine interactions may play a key role in the striatal ischemic insult.Keywords
This publication has 36 references indexed in Scilit:
- Correlation between amino acid release and neuropathologic outcome in rat brain following middle cerebral artery occlusion.Stroke, 1990
- Stroke and its modification in Parkinson's disease.Stroke, 1990
- Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's diseaseTrends in Neurosciences, 1990
- Dopamine depletion protects striatal neurons from ischemia-induced cell deathLife Sciences, 1988
- Extracellular levels of amino acids in striatum and globus pallidus of 6-hydroxydopamine-lesioned rats measured with microdialysisActa Physiologica Scandinavica, 1986
- N-Methylaspartate-Evoked Liberation of Taurine and Phosphoethanolamine In Vivo: Site of ReleaseJournal of Neurochemistry, 1985
- Effect of Glutamine on Glutamate Release from Hippocampal Slices Induced by High K+ or by Electrical Stimulation: Interaction with Different Ca2+ ConcentrationsJournal of Neurochemistry, 1985
- Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral MicrodialysisJournal of Neurochemistry, 1984
- Temporal profile of neuronal damage in a model of transient forebrain ischemiaAnnals of Neurology, 1982
- Inhibitory effects of dopamine on high affinity glutamate uptake from rat striatumLife Sciences, 1982