Intracarotid slow bolus injection of nimodipine during angiography for treatment of cerebral vasospasm after SAH
- 1 August 1984
- journal article
- case report
- Published by Journal of Neurosurgery Publishing Group (JNSPG) in Journal of Neurosurgery
- Vol. 61 (2), 231-240
- https://doi.org/10.3171/jns.1984.61.2.0231
Abstract
Nimodipine was given as an intracarotid slow bolus injection in six patients with subarachnoid hemorrhage (SAH) due to rupture of a cerebral aneurysm, with angiographically demonstrated vasospasm. The patients were followed by serial angiograms for demonstration of the effect of nimodipine on vasospasm. After angiography, all patients were treated with a constant venous infusion of this new calcium antagonist. Although the therapeutic regimen was started only a few hours after onset of vasospasm, there was no change in cerebral vessel caliber detectable on angiograms following the intracarotid injection. Three patients died, two patients finally recovered with neurological deficits due to cerebral ischemia, and one patient with asymptomatic vasospasm remained symptom-free. Although nimodipine may act to prevent cerebral vasospasm after SAH, the authors believe that the intracarotid application is not effective after vasospasm has occurred.Keywords
This publication has 29 references indexed in Scilit:
- Cerebral Arterial Spasm – A Controlled Trial of Nimodipine in Patients with Subarachnoid HemorrhageNew England Journal of Medicine, 1983
- Prevention of symptomatic vasospasm by topically applied NimodipineActa Neurochirurgica, 1982
- The pathophysiology of cerebral vasospasm, and pharmacological approaches to its managementActa Neurochirurgica, 1982
- Nimodipine: a new calcium antagonistic drug with a preferential cerebrovascular actionActa Neurochirurgica, 1982
- Cerebral arterial contractions induced by human and bovine thrombin.Stroke, 1980
- Effect of Ca2+ Antagonists on Experimental Cerebral VasospasmNeurologia medico-chirurgica, 1980
- Prolonged contraction of isolated human and canine cerebral arteries induced by uridine 5'-triphosphate.Stroke, 1978
- Cerebral Vasospasm with Ruptured Saccular Aneurysm — The Clinical ManifestationsNeurosurgery, 1977
- Cerebral arterial smooth muscle contraction by thromboxane A2.Stroke, 1977
- Cerebral arterial spasmJournal of Neurosurgery, 1974