INVIVO MEASUREMENT OF P-31 NUCLEAR MAGNETIC-RESONANCE SPECTRUM OF AGING MOUSE-BRAIN
- 1 January 1983
- journal article
- research article
- Vol. 15 (1), 13-17
Abstract
31P nuclear magnetic resonance spectra of the brains of young, mature and old C57BL/6 mice were measured in vivo. Under normal conditions, no significant changes with age were observed in the spectra and there were no statistically significant age-related differences in the ratio of phosphocreatine to ATP. When the animals were stressed by subjecting them to O2 restriction, the young and mature mice showed no change in the ratio, whereas it increased in the old mice. Energy metabolism apparently is unimpaired in the brains of unstressed old animals but that ATP synthesis may be decreased with age in a stressed animal.This publication has 4 references indexed in Scilit:
- Assessment of Pharmacological Treatment of Myocardial Infarction by Phosphorus-31 NMR with Surface CoilsScience, 1981
- Mapping of metabolites in whole animals by 31P NMR using surface coilsNature, 1980
- Detection of 31 P nuclear magnetic resonance signals in brain by in vivo and freeze-trapped assaysProceedings of the National Academy of Sciences, 1978
- Restitution of ATP and Creatine Phosphate after Experimental Depletion in Young, Adult, and Old RatsGerontology, 1978