BODY CHOLESTEROL METABOLISM IN MAN. I. THE EQUILIBRATION OF SERUM AND TISSUE CHOLESTEROL*†
Open Access
- 1 September 1962
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 41 (9), 1732-1737
- https://doi.org/10.1172/jci104631
Abstract
The rate of equilibration of serum and tissue cholesterol has been studied in 9 human patients who died 1 to 226 days after receiving C14-labeled cholesterol. The cholesterol in all tissues excepting brain and blood vessels attained complete equilibration with serum cholesterol within 1 month. The brain cholesterol showed only negligible degrees of equilibration with serum cholesterol throughout the study. Complete equilibration of normal arterial intimal cholesterol with serum cholesterol was observed after prolonged periods, indicating that the cholesterol in normal vessels is in a dynamic state of equilibrium with serum cholesterol. Significant Cl4-radioactivity was present in atherosclerotic plaques although the presence of atherosclerosis appeared to retard the rate at which equilibration with serum cholesterol occurred.This publication has 10 references indexed in Scilit:
- BODY CHOLESTEROL METABOLISM IN MAN. II. MEASUREMENT OF THE BODY CHOLESTEROL MISCIBLE POOL AND TURNOVER RATE*†Journal of Clinical Investigation, 1962
- METABOLISM OF INTRAVENOUSLY INFUSED C14-LABELED CHOLESTEROL IN EUTHYROIDISM AND MYXEDEMA1961
- Passage of Labeled Cholesterol into the Aortic Wall of the Normal DogCirculation Research, 1959
- Species Differences in Cholesterol Biosynthesis by Arterial Tissue.Experimental Biology and Medicine, 1958
- A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUESJournal of Biological Chemistry, 1957
- The origin of plasma cholesterol and the rates of equilibration of liver, plasma, and erythrocyte cholesterol.1955
- The use of C14-labeled acetate to study cholesterol metabolism in man.1955
- CHOLESTEROL SYNTHESIS FROM C14—ACETATE IN MAN 1Journal of Clinical Investigation, 1954
- Studies on the biosynthesis of cholesterol. III. Purification of C14-cholesterol from perfusions of livers and other organsArchives of Biochemistry and Biophysics, 1952
- Observations on the Fate of Ingested Cholesterol in ManCirculation, 1952