Local production of mumps IgG and IgM antibodies in the cerebrospinal fluid of meningitis patients
- 1 January 1981
- journal article
- research article
- Published by Wiley in Journal of Medical Virology
- Vol. 8 (4), 257-265
- https://doi.org/10.1002/jmv.1890080406
Abstract
Immunoglobulin G (IgG) and M (IgM) antibodies against mumps virus were measured by an enzyme-linked immunosorbent assay (ELISA) in the serum and cerebrospinal fluid (CSF) specimens of patients with mumps meningitis. The CSF IgG antibodies correlated well with the respective antibody titers in serum. On the contrary, in only about half of the patients a moderate correlation was found between the CSF and serum IgM antibody titers, while the other patients did not have detectable mumps IgM antibodies in CSF irrespective of intermediate to high titers in serum. Two different immunologic mechanisms may be involved in these two groups which, however, did not show any clinical differences. The lack of IgM antibodies in the CSF of many patients diminished the value of CSF in the laboratory diagnosis of mumps meningitis compared to use of serum specimens. Intrathecal synthesis of mumps IgG antibodies was demonstrated in 83% of the patients, and of IgM antibodies in at least 67% of those patients with detectable IgM antibodies in CSF. The ratio between mumps IgG and IgM antibodies was higher in CSF than in serum, suggesting that the synthesis of IgG antibodies in central nervous system was more efficient than that of IgM antibodies.Keywords
This publication has 23 references indexed in Scilit:
- Mumps‐specific immunoglobulin M and G antibodies in natural mumps infection as measured by enzyme‐linked immunosorbent assayJournal of Medical Virology, 1981
- Immunoglobulins to tick-borne encephalitis in the cerebrospinal fluid of manJournal of Medical Virology, 1979
- Multiple Sclerosis: Local Synthesis of Electrophoretically Restricted Measles, Rubella, Mumps and Herpes Simplex Virus Antibodies in the Central Nervous SystemScandinavian Journal of Immunology, 1978
- Demonstration of cerebrospinal fluid lymphocytes sensitized against virus antigens in mumps meningitisActa Neurologica Scandinavica, 1978
- Relative Concentrations of Albumin and IgG in Cerebrospinal Fluid in Health and in Acute MeningitisScandinavian Journal of Infectious Diseases, 1978
- MEASLES-VIRUS-SPECIFIC IMMUNOGLOBULIN-M RESPONSE IN SUBACUTE SCLEROSING PANENCEPHALITISThe Lancet, 1977
- A follow‐up study of a child psychiatric clientele with special regard to the diagnosis of psychosisActa Psychiatrica Scandinavica, 1976
- Passive Hemagglutinating Antibodies in Cerebrospinal Fluids in Herpesvirus Hominis EncephalitisExperimental Biology and Medicine, 1972
- Immunoglobulins in Multiple Sclerosis and Infections of the Nervous SystemArchives of Neurology, 1971
- Involvement of the Central Nervous System in MumpsActa Medica Scandinavica, 1943