T-cell lymphomas in adults: A clinicopathological study of eighteen cases
- 1 June 1987
- journal article
- research article
- Published by Wiley in The Journal of Pathology
- Vol. 152 (2), 63-76
- https://doi.org/10.1002/path.1711520202
Abstract
Eighteen cases of adult T-cell lymphoma have been studied with respect to clinical presentation, response to treatment, histology, enzyme histochemistry, immunocytochemistry, and gene rearrangement. Seven cases (39 per cent) presented at extra-nodal sites, and the age range was from 18 to 79. Treatment was with combination chemotherapy in most cases, and 11 of the 18 patients died within the three year follow-up period. The lymphomas were classified morphologically into six types; T-lymphoblastic lymphoma (TLL), angioimmunoblastic lymphadenopathy (AIL)-like T-cell lymphoma, T-zone lymphoma, pleomorphic mixed medium and large cell T-cell lymphoma (PMMLC), pleomorphic large cell T-cell lymphoma (PLC), and monomorphic large cell T-cell lymphoma (MLC). Enzyme histochemistry was found to be of limited value in the identification of T-cell lymphomas. Immunocytochemistry showed a degree of correlation between the immunological profile and morphology, with cases in the PLC and MLC groups showing limited expression of T-cell antigens. Re-arrangement of the β chain of the T-cell receptor gene was detected in 12 of the 14 cases studied, and all showed germ-line immunoglobulin genes. The study emphasizes the varied morphological and clinical appearances of adult T-cell lymphoma.Keywords
This publication has 47 references indexed in Scilit:
- Response to 2'-deoxycoformycin after failure of interferon-alpha in nonsplenectomized patients with hairy cell leukemiaBlood, 1986
- Lymphoblastic lymphoma: an immunophenotype study of 26 cases with comparison to T cell acute lymphoblastic leukemiaBlood, 1986
- Biopsy Pathology of the Lymphoreticular SystemPublished by Springer Nature ,1983
- Cytochemical reactivity of T? lymphocytes in human lymphatic tissue for dipeptidylaminopeptidase IVJournal of Molecular Histology, 1982
- National cancer institute sponsored study of classifications of non-hodgkin's lymphomas. Summary and description of a working formulation for clinical usageCancer, 1982
- Distinctive functional characteristics of human „T”︁ lymphocytes defined by E rosetting or a monoclonal anti‐T cell antibodyEuropean Journal of Immunology, 1981
- A critical analysis of the classifications of non-Hodgkin's lymphomasCancer, 1979
- A human thymocyte antigen defined by a hybrid myeloma monoclonal antibodyEuropean Journal of Immunology, 1979
- Studies on glycyl-proline naphthylamidaseHistochemistry and Cell Biology, 1977