Diffusional and electrokinetic redistribution at the synapse: A physicochemical basis of synaptic competition
- 1 January 1990
- journal article
- review article
- Published by Wiley in Journal of Neurobiology
- Vol. 21 (1), 157-168
- https://doi.org/10.1002/neu.480210111
Abstract
Coinnervating nerve terminals may compete for “stabilizing factors” confined within the postsynaptic cell. The competition could be achieved through a diffusion‐mediated trapping the factor, facilitated by an activity‐dependent electrokinetic migration of the factor toward the synaptic site. We have examined the evidence for diffusional and electrokinetic motions of cell surface and cytoplasmic components, the profile and magnitude of the electric field produced by the synaptic current, and the plausibility that these motions underlie the process of synaptic competition.Keywords
This publication has 49 references indexed in Scilit:
- The influence of neuronal activity on patterns of synaptic connectionsTrends in Neurosciences, 1987
- Contact-induced redistribution of specific membrane components: local accumulation and development of adhesion.The Journal of cell biology, 1986
- Spontaneous release of transmitter from growth cones of embryonic neuronesNature, 1983
- Acetylcholine release from growth cones detected with patches of acetylcholine receptor-rich membranesNature, 1983
- Redistribution of cell surface receptors induced by cell-cell contact.The Journal of cell biology, 1982
- Rapid lateral diffusion of functional ACh receptors in embryonic muscle cell membraneNature, 1982
- IN SITU ELECTROPHORESIS OF MEMBRANE COMPONENTSAnnual Review of Biophysics and Bioengineering, 1981
- The elimination of synapses in multiply-innervated skeletal muscle fibres of the rat: dependence on distance between end-platesBrain Research, 1977
- Development of the myotomal neuromuscular junction in Xenopus laevis: An electrophysiological and fine-structural studyDevelopmental Biology, 1977
- Electrotonic Spread of Dendritic Potentials in Feline Pyramidal CellsScience, 1968