BINDING OF HEMATOPORPHYRIN DERIVATIVE TO HUMAN SERUM ALBUMIN
- 1 July 1984
- journal article
- research article
- Published by Wiley in Photochemistry and Photobiology
- Vol. 40 (1), 1-4
- https://doi.org/10.1111/j.1751-1097.1984.tb04545.x
Abstract
Dialysis of hematoporphyrin derivative fraction A (HpD‐A) off human serum albumin at 38°C followed the Hill equation for cooperative binding with saturation at 5 to 8. 600 dalton porphyrin units. Approximately 15% of the HpD‐A was free for concentrations typical of human serum in photoradiation therapy. Possible structures of the tumor‐localizing and ‐photosensitizing component in HpD‐A are considered. Of these, a folded‐over, covalent dimer appears to be more consistent with the photophvsical properties.Keywords
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