Familial 13–15 Translocation Abnormality (Denver Classification) Associated with One Case of Cerebral Palsy
- 11 July 1963
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 269 (2), 66-69
- https://doi.org/10.1056/nejm196307112690202
Abstract
IN 1960 Lejeune et al.1 noted a centric fusion of 2 13–15 chromosomes in the cells of a person with Klinefelter's syndrome, and in 1962 Walker and Harris2 , 3 reported several generations of a family with cases of similar translocation. In the study presented here, a family with a possible mosaicism for a similar translocation is described. Interest in the family sprang from the observed coincidence of cerebral palsy in 2 and anencephaly in a third member of the third generation.Methods and MaterialsEighteen members (Fig. 1) representing three generations were studied by means of the modified leukocyte-culture technic4 for . . .Keywords
This publication has 4 references indexed in Scilit:
- Familial transmission of a translocation between two chromosomes of the 13?15 group (Denver classification)Annals of Human Genetics, 1962
- Investigation of Family Showing Transmission of a 13-15 Chromosomal Translocation (Denver Classification)BMJ, 1962
- Chromosome preparations of leukocytes cultured from human peripheral bloodExperimental Cell Research, 1960
- A Universal Stain for the Sex Chromatin BodyStain Technology, 1957