Silent Nucleotide Substitutions and the Molecular Evolutionary Clock
- 28 November 1980
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 210 (4473), 973-978
- https://doi.org/10.1126/science.7434017
Abstract
Half of the nucleotide substitutions during the evolutionary divergence of genes in animals, bacteria, and viruses are silent changes. These result from an inherent biochemical property of DNA and are fixed by genetic drift. Evolution may be viewed as a device for protecting DNA molecules from extinction.This publication has 41 references indexed in Scilit:
- Selfish DNA: the ultimate parasiteNature, 1980
- Nucleotide sequence and genetic organization of the polyoma late region: Features common to the polyoma early region and SV40Cell, 1979
- Evolutionary nucleotide replacements in DNANature, 1979
- Evolution of the three overlapping gene systems in G4 and φX174Journal of Molecular Biology, 1979
- The nucleotide sequence and genome organization of the polyoma early region: Extensive nucleotide and amino acid homology with SV40Cell, 1979
- The DNA sequence of sea urchin (S. purpuratus) H2A, H2B and H3 histone coding and spacer regionsCell, 1978
- Nucleotide sequence of bacteriophage φX174 DNANature, 1977
- Studies on the bacteriophage MS2: XXXIII. Comparison of the nucleotide sequences in related bacteriophage RNAsJournal of Molecular Biology, 1976
- Estimation of evolutionary changes in certain homologous polypeptide chainsJournal of Molecular Biology, 1972
- Improved procedures for comparing homologous sequences in molecules of proteins and nucleic acidsJournal of Molecular Biology, 1972