The in vitro hydroxylation of 4′-chloro-4-biphenylol by a mushroom tyrosinase preparation
- 1 January 1976
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Microbiology
- Vol. 22 (1), 104-106
- https://doi.org/10.1139/m76-014
Abstract
Incubation of 4′-chloro-4-biphenylol with a mushroom tyrosinase preparation gave the catechol, 4′-chIoro-3,4-biphenyldiol as the sole in vitro metabolite. This compound was identical with the major rat urinary metabolite of 4′-chloro-4-biphenylol and thus confirms the structure assigned to the metabolite. This result also demonstrates a possible degradation pathway of hydroxylated chlorobiphenyls which are themselves the major metabolic degradation products of polychlorinated biphenyls.This publication has 1 reference indexed in Scilit:
- Polychlorinated biphenyls: Hydroxylated urinary metabolites of 2,5,2′,5′-tetrachlorobiphenyl identified in rabbitsBiochemical and Biophysical Research Communications, 1973