EFFECT OF OXALIC ACID INTRAVENOUSLY ON BLOOD-COAGULATION TIME IN THREE HEMOPHILIACS

Abstract

Three hemophiliacs with prolonged coagulation times were given oxalic acid intraven. and their coagulation times studied. The coagulation of each decreased to normal (10 mins. or less) in 2 or 3 days. Oxalic acid was then stopped, following which the coagulation time increased at different rates until the coagulation time approximated that before oxalic acid was given. The modus operandi of the decrease in coagulation time was not known. No evidence of toxicity was present in any of the 3 patients who received oxalic acid intraven. Results indicated that oxalic acid could not be considered as a cure for hemophilia. Its use, along with other known beneficial measures, notably multiple transfusions, would possibly be warranted in attempting to control bleeding.