BINDING PROPERTIES AND SPECIFICITY OF C-REACTIVE PROTEIN
- 1 March 1967
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 57 (3), 706-712
- https://doi.org/10.1073/pnas.57.3.706
Abstract
This communication provides evidence that the precipitation reaction between C-reactive protein (CRP) and C-polysaccharide can be specifically inhibited by various phosphate monoesters of low molecular weight. In studying the mechanism of this inhibition reaction, it was found that the CRP can bind approximately 1 molecule of phosphate monoester per protein subunit and that the binding is dependent on the presence of calcium ions. CRP was found to bind calcium ions in the absence of phosphate mono-esters.This publication has 9 references indexed in Scilit:
- Peptide-Protein Interaction as Studied by Gel Filtration*Biochemistry, 1966
- C-reactive protein: a molecule composed of subunits.Proceedings of the National Academy of Sciences, 1965
- Some Biochemical and Serologic Properties of the Pneumococcal C Polysaccharide.Experimental Biology and Medicine, 1963
- The Chemical Composition of Pneumococcal C-PolysaccharideJournal of Biological Chemistry, 1963
- Measurement of protein-binding phenomena by gel filtrationBiochimica et Biophysica Acta, 1962
- THE OCCURRENCE OF POLYGLYCEROPHOSPHATE AS AN ANTIGENIC COMPONENT OF VARIOUS GRAM-POSITIVE BACTERIAL SPECIESThe Journal of Experimental Medicine, 1959
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951
- THE MEASUREMENT OF C-REACTIVE PROTEIN IN HUMAN SERA. COMPARISON OF THE CLINICAL TESTS ON THE BASIS OF A QUANTITATIVE METHODJournal of Clinical Investigation, 1951
- THE OCCURRENCE IN THE RABBIT OF AN ACUTE PHASE PROTEIN ANALOGOUS TO HUMAN C-REACTIVE PROTEINThe Journal of Experimental Medicine, 1951