Polyamine Depletion Influences Drug-Induced Chromosomal Damage
- 10 September 1982
- journal article
- retracted article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 217 (4564), 1044-1046
- https://doi.org/10.1126/science.6810463
Abstract
Polyamines have been implicated in the intracellular stabilization of DNA. Depletion of intracellular polyamines influences the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and cis-diamminedichloroplatinum II. By means of the sister chromatid exchange assay, it was found that intracellular polyamine depletion can also alter the induction of chromosomal damage by these cytotoxic agents.This publication has 17 references indexed in Scilit:
- Depletion of 9L rat brain tumor cell polyamine content by treatment with -?-difluoromethylornithine inhibits proliferation and the G1 to S transitionExperimental Cell Research, 1981
- SISTER CHROMATID EXCHANGEAnnual Review of Genetics, 1977
- Resolution of α, β and γ DNA of Saccharomyces cerevisiae with the antitumor drug cis-Pt(NH3)2Cl2. Evidence for preferential drug binding by GpG sequences of DNAJournal of Molecular Biology, 1976
- Sister chromatid exchanges—A sensitive assay of agents damaging human chromosomesMutation Research, 1975
- New Giemsa method for the differential staining of sister chromatidsNature, 1974
- Binding of cis- and trans-dichlorodiammineplatinum(II) to nucleosides.i. Location of the binding sitesJournal of the American Chemical Society, 1973
- Inhibitory effects of anti‐tumor platinum compounds on DNA, RNA and protein syntheses in mammalian cells in vitroInternational Journal of Cancer, 1970
- Complexes between DNA and polyamines: a molecular modelJournal of Molecular Biology, 1967
- The crystal structures of cis- and trans-dichlorodiammineplatinum(II)J. Chem. Soc. A, 1966
- The molecular configuration of deoxyribonucleic acidJournal of Molecular Biology, 1960