Clinical and Physiologic Studies in a Negro with Sickle-Cell Hemoglobin D Disease

Abstract

HEMOGLOBIN D was the fifth human hemoglobin to be described after hemoglobin A (normal adult), hemoglobin F (normal fetal), hemoglobin S (sickle) and hemoglobin C. It was found with hemoglobin S in 2 white siblings with hemoglobin S-D disease.^{1 , 2} Three additional cases of this disorder have been reported, 2 in Caucasians^{3 , 4} and 1 in a mulatto.⁵ A survey of a nearby city found the incidence of hemoglobin D trait to be 0.85 per 1000 Negroes.⁶ It was suggested that hemoglobin S-D disease was being overlooked in the Negro.Hemoglobin D has the same mobility on filter-paper electrophoresis at pH 8.6 . . .