Structure and variability of human chromosomes analyzed by recent techniques
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 41 (1), 1-9
- https://doi.org/10.1007/bf00278866
Abstract
Besides the AT-specific fluorochromes, GC-specific fluorescent antibiotics are now available for chromosomal analysis. Chromosomal bands represent large accumulation of DNA sequences with similar AT:GC ratio. These uniform differences from the mean AT:GC ratio in the bands can be explained only by at least partial repetition of short DNA sequences in these regions. By comparison of various staining techniques more information also on the constitutive heterochromatin in man becomes available. The human NOR region exhibits a complex organization when studied by various basespecific fluorochromes and silver staining. The DNA-specific fluorochromes are also useful tools in cytophotometric DNA measurements.Keywords
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