INHIBITION OF CARBOHYDRATE METABOLISM OF RAT BRAIN TISSUE BY ADRENOCHROME

Abstract

Adrenochrome has been found to bring about an inhibition of the utilization of glucose, pyruvate, and succinate by minced rat brain preparations under aerobic conditions. The inhibition appears to be largely attributable to the presence of the quinoid structure since alteration of this structure, as in the Girard-T derivative, resulted in a compound that caused little or no inhibition. The implications of these findings are discussed.