Design, synthesis and characterisation of a 34-residue polypeptide that interacts with nucleic acids
- 1 October 1979
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 281 (5733), 650-655
- https://doi.org/10.1038/281650a0
Abstract
Based on secondary structure prediction rules and model building, a neutral artificial 34-residue polypeptide with potential nucleic acid-binding activity was synthesized. This peptide and its covalent dimer showed strong interaction with cytidine phosphates and single-stranded DNA. The dimer had considerable RNase activity with high preference for cleavage at the 3''-end of C.Keywords
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