Optical resolution of mutagenic and carcinogenic derivatives of polyaromatic hydrocarbons by high pressure liquid chromatography on a chiral support

Abstract

Optically active diols of benzo[a]pyrene and benz[a]anthracene, and a benzo[a]pyrene diol–epoxide, were resolved by h.p.l.c. on (R)-(–)-2-(2,4,5,7-tetranitro-9-fluorylideneamino-oxy)propionic acid (TAPA) bonded to silica gel.