More than five years' experience with home dialysis has shown this program to be an effective, safe means of maintaining life for the patient with chronic uremia. It is considerably more economical than center therapy, and rehabilitation can be expected in 90% of patients. Their overall general well-being appears to be greater than those receiving center dialysis. Complications can and do occur. Although potentially fatal, there have been no dialyses-associated fatalities, and morbidity is low. We judge this to be the currently preferred form of therapy for patients awaiting cadaveric transplantation, those unsuitable for having a transplant, geriatric patients, and for any psychologically stable individual who prefers not to receive a transplant.