Extended Therapy of Stage D Carcinoma of the Prostate with Oral Estramustine Phosphate
- 1 April 1976
- journal article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 115 (4), 409-412
- https://doi.org/10.1016/s0022-5347(17)59221-6
Abstract
We treated 50 patients with stage D carcinoma of the prostate with 15 mg. per kg. per day oral estramustine phosphate for 3 to 24 months. We are able to evaluate 44 patients. Objective remissions were induced in 8 of the 44 patients (19 per cent) and subjective remission occurred in all objective responders and in 7 additional patients for a subjective response of 15 of 44 (36 per cent). No hematologic or renal toxicity was encountered. Transient nausea occurred early in half of the patients and was dose limiting in 3 patients. One case of hepatic toxicity was seen. Oral estramustine phosphate is well tolerated and long-term therapy is feasible.Keywords
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