VASCULAR-RESPONSES OF ISOLATED CANINE INTERMEDIATE AURICULAR ARTERY TO VASOACTIVE SUBSTANCES
- 1 January 1984
- journal article
- research article
- Vol. 268 (2), 225-231
Abstract
The stainless steel cannula inserting method was used to observe the effects of 7 vasoactive substances in the isolated intermediate auricular artery of the dog. The isolated artery was suspended in a bath at 37.degree. C and perfused with Ringer-Locke solution under a constant flow rate. Drugs were administered in the endothelial side of the artery through a cannulated tubing and the response was obtained as changes in perfusion pressure. 5-Hydroxytryptamine (5-HT), norepinephrine (NE), tyramine, ATP and prostaglandin F2.alpha. (PGF2.alpha.) increased perfusion pressure in a dose-related manner. The order of potency for inducing vasoconstriction was 5-HT > NE = PGF2.alpha. > tyramine > ATP > KCl. Histamine caused either slight biphasic responses or no change in perfusion pressure. The canine auricular artery would be a good in vitro model for studying pharmacological responses of cutaneous vessels.This publication has 5 references indexed in Scilit:
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