Paederus dermatitis in Egypt: a clinicopathological and ultrastructural study
- 2 September 2010
- journal article
- Published by Wiley in Journal of the European Academy of Dermatology and Venereology
- Vol. 24 (10), 1197-1201
- https://doi.org/10.1111/j.1468-3083.2010.03621.x
Abstract
Outbreaks of paederus dermatitis (PD) have been observed in different parts of the world, yet the histopathological and ultrastructural changes and their relationship to pederin toxin have not been described. To describe the clinical presentations of PD in Egypt and to study the effects of pederin toxin on the skin by evaluating the histopathological and ultrastructural changes of some representative cases. One hundred and thirteen patients with PD were studied clinically and epidemiologically. Skin biopsies were taken from 40 patients for histopathological examination and from 20 patients for electron microscopic (EM) examination. Clinically, the most common presentation comprised erythematous plaques with micropustules. Blisters exhibited a linear configuration in 40% of the patients and kissing lesions were observed in 13%. Multiple lesions occurred in 78% of the patients and the face was the most commonly involved site (48%). The insect was identified as Paederus alfierii. Histopathological examination revealed features of acute irritant dermatitis in the upper epidermis. Mitotic figures and apoptotic changes such as chromatin condensation and DNA fragmentation were identified in the basal and suprabasal layers. These features were confirmed by EM. Clinical, histopathological and, for the first time, ultrastructural characteristics of paederus dermatitis are described. The pathological abnormalities of the upper epidermis are caused by the irritant effect of pederin toxin. The presence of apoptosis within the lower epidermis can be related to this toxin, a point that needs further research, hoping for its future implications in the management of hyperproliferative disorders.Keywords
This publication has 18 references indexed in Scilit:
- An outbreak of 268 cases of Paederus dermatitis in a toy‐building factory in central ChinaInternational Journal of Dermatology, 2009
- An outbreak of Paederus dermatitis in a suburban hospital in South India: A report of 123 cases and review of literatureJournal of the American Academy of Dermatology, 2007
- Paederus dermatitisIndian Journal of Dermatology, Venereology and Leprology, 2007
- An outbreak of paederus dermatitis in a suburban hospital in Sri LankaInternational Journal of Dermatology, 1997
- Dermatite de contato pela pederina, estudo clínico e epidemiológico no estado do Ceará, BrasilRevista do Instituto de Medicina Tropical de São Paulo, 1994
- Paederus dermatitis – a mimicContact Dermatitis, 1993
- Paederus dermatitis: An easy diagnosable but misdiagnosed eruptionEuropean Journal of Pediatrics, 1993
- Paederus fuscipes DermatitisThe American Journal of Dermatopathology, 1991
- STUDIES ON THE MECHANISM OF ACTION OF PEDERINEThe Journal of cell biology, 1968