Prenatal treatment with 6‐hydroxydopa and DSP 4: Biochemical, endocrinological and behavioural effects
- 1 January 1985
- journal article
- Published by Wiley in International Journal of Developmental Neuroscience
- Vol. 3 (5), 501-509
- https://doi.org/10.1016/0736-5748(85)90039-5
Abstract
Biochemical, hormonal, and behavioural aspects of the effects of prenatal treatment (foetal days 18 and 19) with 6-hydroxydopa (2 × 40 mg/kg) and DSP 4 (2 × 20 mg/kg) have been studied in the rat. The results of the catecholamine assays suggest that the 6-hydroxydopa treatment produced a transient decrease of noradrenaline concentration in the cerebral cortex, and a long-lasting decrease in the cerebellum, whereas DSP 4 produced a long-lasting decrease in the cerebral cortex and a tendency towards increase in the cerebellum. Assays of adrenocorticotropic hormone and corticosterone indicated a general tendency towards increase in base line as well as in moderate stress situations. The results of behavioural tests indicated hyperactivity and/or hyperreactivity, but not restlessness, and partly supranormal sensorimotor performances.Keywords
This publication has 27 references indexed in Scilit:
- Effects of the noradrenaline neurotoxin DSP 4 on monoamine neurons and their transmitter turnover in rat CNSJournal of Neural Transmission, 1984
- Corticosterone secretion in the rat after DSP-4 treatmentNeuroscience Letters, 1984
- Novelty-oriented behavior in the rat after selective damage of locus coeruleus projections by DSP-4, a new noradrenergic neurotoxinPharmacology Biochemistry and Behavior, 1984
- Effects of the noradrenaline neurotoxin DSP4 on the postnatal development of central noradrenaline neurons in the ratNeuroscience, 1982
- Developmental Localization of Noradrenergic Innervation to the Rat Cerebellum Following Neonatal 6-Hydroxydopa and Morphine TreatmentDevelopmental Neuroscience, 1982
- DSP4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine)—A useful denervation tool for central and peripheral noradrenaline neuronsEuropean Journal of Pharmacology, 1981
- Effects of neonatal 6-hydroxydopamine treatment on catecholamine levels and behavior during development and adulthoodPsychopharmacology, 1981
- DSP-4: A novel compound with neurotoxic effects on noradrenergic neurons of adult and developing ratsBrain Research, 1980
- Age-dependent effects of 6-hydroxydopamine on locomotor activity in the ratBrain Research, 1979
- Neonatal treatment with 6-OH-DA affects brain NE content but not behaviorPhysiological Psychology, 1977