Use of Cyclosporin-A despite Renal Dysfunction

Abstract

To the Editor: Cyclosporin A (CyA) is a potent immunosuppressive agent,¹ and its initial use in renal, hepatic, and pancreatic transplantation in human beings has been extremely promising.² Until recently, however, the mode of degradation and elimination of CyA was uncertain. This factor, in combination with the legitimate concern of excessive immunosuppression and the demonstrated adverse effects of hepatotoxicity and nephrotoxicity, raised the important question of whether CyA could be administered safely during primary graft nonfunction after renal transplantation. Presented here is a case history suggesting that with continued pharmacologic monitoring, CyA can be safely administered during a period of . . .