To the surgeons who steadily spend thought, time, and a great deal of energy trying to eradicate cancer, it is truly encouraging to know that a patient with four primary successive major malignancies over a 21-year period was cured of three of them and survived the fourth by 7 years. With more than five years passing after the last cancer operation, it was hoped that surgery had once more triumphed, but such was not the case. It is believed, however, that a report of this nature will help sustain the continuing attack on this distressing disease, since, as the life span of our population becomes greater, surgeons may expect to be confronted with an increasing incidence of a cured first cancer and the subsequent development of a second, third, or even a fourth primary tumor. A brief review of this rare and interesting case is presented and added to similar