A convenient synthesis of 9-(2-hydroxyethoxymethyl)guanine(acyclovir) and related compounds.
- 1 January 1988
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 36 (3), 1153-1157
- https://doi.org/10.1248/cpb.36.1153
Abstract
A convenient and economical synthesis of 9-(2-hydroxyethoxymethyl)guanine (1, acyclovir, Zovirax, or acyclic guanosine: an antiherpetic agent) from guanine was developed via N2,O-diacetylacyclovir. Two closely related compounds, N2-acetylacyclovir (7) and O-acetylacyclovir (8), were also prepared by selective deacetylation.This publication has 6 references indexed in Scilit:
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