THE EFFECT OF PURIFIED BOVINE THYROIDSTIMULATING HORMONE IN MAN. 1. DOSERESPONSE CHARACTERISTICS STUDIED WITH I132*

Abstract

The effect of a highly purified bovine thyrotropin (TSH) was studied in 12 human volunteers. The response was measured by the rise in the two-hour thyroidal uptake of I132. Dose-response curves for purified TSH, and for a commercial preparation (Thytropar) given in equivalent units, did not differ significantly. After TSH stimulation, the thyroidal I132 uptake following intravenous administration of I132 showed an increase of borderline significance compared with the uptake following oral administration, whereas control uptakes did not differ significantly for the two routes. The refrigerated purified preparation of TSH maintained its potency for as long as a month after reconstitution.