Computed Tomographic Measurement of the Xenon Brain—Blood Partition Coefficient and Implications for Regional Cerebral Blood Flow: A Preliminary Report

Abstract

The calculation of regional cerebral blood flow requires, in addition to the measurement of the clearance, a knowledge of the regional brain-blood partition coefficient. The usual 133Xe washout techniques do not measure this latter parameter but use published values for normal brain tissue. This may lead to large errors in pathological tissue because the partition coefficient changes significantly in brain tumors. Investigations have begun into the use of CT [computed tomography] and stable Xe to produce a cross sectional view of the brain in terms of its brain-blood partition coefficients. Results of experiments using an I phantom and Xe inhalation in animals [dogs] are presented.