EXPERIMENTAL ARTHRITIS IN THE RABBIT. A CONTRIBUTION TO THE PATHOGENY OF ARTHRITIS IN RHEUMATIC FEVER

Abstract

By a process of sensitization described it was found possible to cause arthritis in rabbits constantly after one intravenous injection of the streptococcus. This reaction is specific. By intravenous inoculation, without previous sensitization, of the streptococcus used in these experiments it was possible to cause arthritis in rabbits only after three or more injections. An analogy is suggested between the arthritis induced by sensitization and the relapses in human rheumatic fever. A further analogy is suggested between the development in rabbits of arthritis after repeated intravenous injections and the development of the primary lesion in human rheumatic fever.