Cotton Rats and White Mice in Poliomyelitis Research

Abstract

Both cotton rats and white mice are relatively resistant to infection with recently isolated polio virus and are thus not suitable for primary isolations. Both spp. are uniformly susceptible to a monkey-adapted Lansing strain and symptoms of exptl. infections are distinct. It is possible to test for the presence of virus-neutralizing substances in human sera by means of protection tests against the Lansing strain of the virus.