Retrograde Amnesia Produced by Intraperitoneal Injection of Physostigmine
- 19 May 1967
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 156 (3777), 973-974
- https://doi.org/10.1126/science.156.3777.973
Abstract
Intraperitoneal injection of physostigmine in rats produced a retrograde amnesia of a trained task of escaping shock. This amnesic effect was a U-shaped function of the length of the interval between initial training and injection. In all cases, retraining Occurred 30 minutes after injection. A substantial effect was produced by physostigmine if its application was made 30 minutes after training; there was no effect if application and tests were made 1, 2, or 3 days after the original training. When the substance was injected and the rats were retrained 5, 7, or 14 days after the original training, a substantial effect again appeared. These results are similar to those reported in experiments in which another anticholinesterase, diisopropyl fluorophosphate, was applied intracerebrally. The data demonstrate a similar pattern of change of the amnesia with time, and they substantiate the view that neither the place of application nor the brain lesions caused the reported amnesia.This publication has 4 references indexed in Scilit:
- Amnesia or Reversal of Forgetting by Anticholinesterase, Depending Simply on Time of InjectionScience, 1966
- Anticholinesterase-Induced Amnesia and Its Temporal AspectsScience, 1966
- Effects of cholinergic drugs on hypothalamic self-stimulation response rates of dogsAmerican Journal of Physiology-Legacy Content, 1963
- Higher Nervous Function: The Physiological Bases of MemoryAnnual Review of Physiology, 1962