3D 31P Spectroscopic Imaging of the Human Heart at 4.1 T
- 1 March 1995
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 33 (3), 427-431
- https://doi.org/10.1002/mrm.1910330318
Abstract
High field (4 Tesla) spectroscopic imaging offers the advantages of increased signal-to-noise ratio and the possibility of acquiring high resolution metabolite images. We have applied a three dimensional spectroscopic imaging sequence using a sparse Gaussian sampling method to acquire phosphocreatine (PCr) images of the human heart with 8-cc voxels. PCr images enabled observation of the septum, left ventricular free wall, apex, and skeletal muscle. Quantitative evaluation of the 50 myocardial voxels acquired from 10 studies of healthy adults revealed a PCr/adenosine triphosphate (ATP) ratio of 1.80 ± 0.32 after correction for saturation effects. Due to the small size of the voxels and the ability to choose the location of the volumes to minimize inclusion of blood, no correction for blood pool ATP was required. The calculated PCr/ATP ratio is in agreement with other studies at 1.5 and 4.0 T.Keywords
This publication has 17 references indexed in Scilit:
- 31P NMR spectroscopy of the human heart at 4 T: Detection of substantially uncontaminated cardiac spectra and differentiation of subepicardium and subendocardiumMagnetic Resonance in Medicine, 1992
- Correcting human heart 31P NMR spectra for partial saturation. Evidence that saturation factors for PCr/ATP are homogeneous in normal and disease statesJournal of Magnetic Resonance (1969), 1991
- Altered myocardial high-energy phosphate metabolites in patients with dilated cardiomyopathyAmerican Heart Journal, 1991
- Regional Myocardial Metabolism of High-Energy Phosphates during Isometric Exercise in Patients with Coronary Artery DiseaseNew England Journal of Medicine, 1990
- Phosphate metabolite imaging and concentration measurements in human heart by nuclear magnetic resonanceMagnetic Resonance in Medicine, 1990
- Phosphorus‐31 magnetic resonance spectroscopy in humans by spectroscopic imaging: Localized spectroscopy and metabolite imagingMagnetic Resonance in Medicine, 1989
- Localized proton spectroscopy using stimulated echoesJournal of Magnetic Resonance (1969), 1987
- Stabilization of a derangement in adenosine triphosphate metabolism during sustained, partial ischemia in the dog heartJournal of the American College of Cardiology, 1986
- The intrinsic signal‐to‐noise ratio in NMR imagingMagnetic Resonance in Medicine, 1986
- Highly selective π2 and π pulse generationJournal of Magnetic Resonance (1969), 1984