B CELL ANTIBODIES AND CROSSMATCHING
- 1 March 1980
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 29 (3), 227-229
- https://doi.org/10.1097/00007890-198003000-00013
Abstract
Over 200 cadaver donor transplants were crossmatched against T and B lymphocytes at 5 and 37 C. Of 54 positive B cell crossmatches, one-half had cold antibodies and one-half had warm antibodies. The 1-year transplant survival was 58% for B-cold-positive crossmatches and 42% for B-warm-positive crossmatches. The B-warm-positive crossmatches, when subdivided into those with strong HLA-DR antibodies showed a 27% 1-year transplant survival rate. We conclude that B cell-positive crossmatches with HLA-DR antibodies are deleterious and that those with cold anti-IgM antibodies may enhance graft survival.This publication has 11 references indexed in Scilit:
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