Cobalt plaque versus enucleation for uveal melanoma: comparison of survival rates.

Abstract

Two hundred and twenty-three patients treated by cobalt plaque for uveal melanoma were compared with 416 patients treated by enucleation for uveal melanoma in terms of patient survival. The median follow-up time for the patients treated by cobalt plaque was 4.3 years. Kaplan-Meier survival curves were calculated up to five years following treatment based on time to tumor-related deaths. Cox''s proportional hazards multivariate analysis was performed to determine which variables were related to melanoma-related deaths while controlling for age, size, and location of the tumors. Statistically significant predictive factors were location of tumor and largest tumor dimension. There was not a statistically significant difference in survival between patients treated by cobalt plaque and those treated by enucleation.