Diphenylhydantoin in the Prevention of Recurring Ventricular Tachycardia
Open Access
- 1 March 1971
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 43 (3), 420-427
- https://doi.org/10.1161/01.cir.43.3.420
Abstract
The efficacy of diphenylhydantoin in preventing recurrent ventricular tachycardia was studied in ten patients, nine of whom had documented coronary heart disease. Prolonged continuous ECG monitoring of up to 72 hr was performed in each case. Oral and intravenous loading doses of 1000 to 1500 mg were given on the first day of therapy to insure rapid attainment of therapeutic blood levels. Diphenylhydantoin was uniformly ineffective in preventing recurrence of ventricular tachycardia despite the presence of what is regarded as adequate therapeutic plasma concentrations (greater than 19.0 µg/ml in five patients, 10.8-18.0 µg/ml in the remaining five) shortly after onset of ventricular tachycardia. Nystagmus was noted in eight patients, but plasma diphenylhydantoin levels varied widely (8.6-35.0 µg/ml) when this sign of neurotoxicity was first detected.Keywords
This publication has 17 references indexed in Scilit:
- The frequency of asymptomatic disturbances of cardiac rhythm and conduction in middle-aged menThe American Journal of Cardiology, 1969
- Treatment of cardiac arrhythmias with phenytoinBMJ, 1969
- Diphenylhydantoin: Pharmacological and clinical useProgress in Cardiovascular Diseases, 1969
- Coronary and precoronary careAmerican Journal Of Medicine, 1969
- The clinical use of diphenylhydantoin (Dilantin) in the treatment and prevention of cardiac arrhythmiasAmerican Heart Journal, 1969
- Intravenous Diphenylhydantoin Sodium (Dilantin) in Cardiac ArrhythmiasDiseases of the Chest, 1967
- Sodium Diphenylhydantoin in the Treatment of Recurrent Cardiac ArrhythmiasJAMA, 1965
- The effect of diphenylhydantoin (Dilantin) sodium on atrial flutter and fibrillation provoked by focal application of aconitine or delphinineAmerican Heart Journal, 1960
- The Use of Diphenylhydantoin (Dilantin) Sodium in the Treatment of Ventricular TachycardiaArchives of Internal Medicine, 1958
- Persistent ventricular pacemaker following basal skull fractureAmerican Heart Journal, 1951