Diastereofacial Controlled Addition Reaction of Alkoxymethylketones Modified by (2R,4R)-2,4-Pentanediol with Organometallics
- 1 November 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 18 (11), 2045-2048
- https://doi.org/10.1246/cl.1989.2045
Abstract
Oxygen functionalized chiral alkoxymethylketone, derived from (2R,4R)-2,4-pentanediol, provided an efficient chiral environment in the reaction with organometallics which resulted in the either stereoselection depending on metal used; i.e., the reactions with MeLi and MeTi(OiPr)3 selectively furnished the corresponding (S)-and (R)-tertiary alcohols, respectively.Keywords
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