Non-Parallel Response of Amylase and Chymotrypsinogen Biosynthesis following Pancreatic Stimulation: a Possible Explanation for Observed Non-Parallelism in Pancreatic Secretion

Abstract

The responses of amylase and chymotrypsinogen to a pancreatic secretory stimulation (intragastric administration of oleic acid or sodium oleate) were compared in rats. This comparison concerned the rates of biosynthesis of the 2 enzymes, their intrapancreatic levels of storage and their rates of excretion in the juice. In each of these 3 steps, the stimulation induced non-parallel courses of amylase and chymotrypsinogen. The non-parallelism in the rates of biosynthesis could not explain the entire non-parallelism observed in the rates of excretion. The mechanism which controls the proportions of the different enzymes in the juice was seemingly different from that which monitors the rates of individual enzymes biosynthesis.