EFFECT OF TOXEMIA ON TOLERANCE FOR DEXTROSE AND ON THE ACTION OF INSULIN

Abstract

In a previous communication, I¹ presented data showing the effect of toxemia on the tolerance for dextrose of rabbits intoxicated with diphtheria toxin. Daily tests for tolerance for dextrose were made on the animals during the course of their toxemia, and a progressive decrease in the tolerance for sugar was noted. The series of observation to be presented in this article were made on rabbits that were treated as described and, in addition, they received uniform doses of insulin each time dextrose was administered. It was thought that by this procedure some analytic information might be obtained as to the effects of toxemia on the tolerance for dextrose and on the action of insulin. Four rabbits were used, one as a control. All food was withdrawn from the cages, but water was allowed, and a single injection of 0.0075 cc. of diphtheria toxin² was given subcutaneously to each animal except