THE ROLE OF IMMUNITY IN THE PATHOGENESIS OF EXPERIMENTAL RETROGRADE PYELONEPHRITIS
Open Access
- 1 June 1964
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 119 (6), 869-879
- https://doi.org/10.1084/jem.119.6.869
Abstract
Retrograde pyelonephritis was produced in rats by the intravesical injection of Proteus mirabilis. When animals were preimmunized against P mirabilis by (a) prior infection, (b) administration of antigen, or (c) passively transferred antiserum, they were resistant to infection by Proteus when challenged by the retrograde route. The protective effect of specific preimmunization in retrograde pyelonephritis indicates that retardation of bacterial growth within the parenchyma of the kidney is a major factor.Keywords
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