Effect of Physical Factors on Radiosodium Clearance from Subcutaneous and Intramuscular Sites in Animals.

Abstract

The removal of Na24 from tissue was measured in animals using a lead shielded Geiger-Mueller tube coupled to an autoscaler and the effect of physical factors on this radio-Na clearance is reported. The avg. clearance rate in 25 control intramusc. injns. was 59.4% activity remaining after 10 min. Decreases in intramusc. clearance rates were demonstrated with application of ice-salt mixtures, radiant heat and pressure cuffs. The avg. subcut. clearance rate in 10 control studies was 75.8% activity remaining in 10 min. This rate of clearance was increased with the addition of hyaluronidase. The clearance of radio-Na from a part does not appear as a straight line function when plotted, and the calculation of per cent activity remaining per unit time is suggested as an expression for determination of clearance rates.