N-Methyl, 5-Methyl Histamine Evokes a Higher Maximal Rate of Gastric Acid Secretion than Histamine

Abstract

In cats with gastric fistulas, the histamine H2 receptor agonist N-methyl, 5-methyl histamine gave a higher maximal rate of acid secretion than histamine. Histamine plus a histamine H1 receptor antagonist [pyrilamine] also gave a higher maximal rate of acid secretion than histamine alone. These findings are compatible with the hypothesis that histamine acts on H1 receptors to inhibit acid secretion.